Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity

US6391870B2 · kind B2 · utility

Assignee

• SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. · IT

Inventors

• Giuseppe Campiani · Siena, IT
• Vito Nacci · Siena, IT
• Patrizia Minetti · Pomezia, IT
• Maria Assunta Di Cesare · Roma, IT

Key dates

• Filing date: Jan 26, 2001
• Grant date: May 21, 2002
• Expiry date: Jan 26, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polycondensated heterocycles with a pyrrole[2,1-b][1,3]benzothiazepine structure of the following formula (I) where the groups are defined as in the description are disclosed. As compared to known antipsychotic agents, these compounds present substantial activity associated with a simultaneous reduction in unwanted extrapyramidal symptoms. These compounds can be formulated in pharmaceutical compositions for the treatment of psychoses such as, for example, schizophrenia.