Heterocyclic compounds

US6391890B1 · kind B1 · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Tine Krogh Jørgensen · Alte Poststraße, DK
• Knud Erik Andersen
• Rolf Hohlweg
• Uffe Bang Olsen
• Erik Fischer · Königstein, DE
• Zdenek Polivka · Praha, CZ
• Kaler Sindelar · Rožmitál pod Třemšínem, CZ

Key dates

• Filing date: Mar 27, 2000
• Grant date: May 21, 2002
• Expiry date: Mar 27, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.