Enediyne derivatives

US6391916B1 · kind B1 · utility

Assignee

• The Hong Kong University of Science and Technology

Inventors

• Wei-Min Dai · Kowloon, CN
• Anxin Wu · Huangyang, CN
• Yuk Ha Lee · Sha Tin, CN
• Wataru Hamaguchi · Tsukuba, JP
• Sei-ichi Nishimoto · Nara, JP
• Ling Zhou · San Jose, US
• Atsushi Ishii · Imabari, JP

Key dates

• Filing date: Jul 21, 2000
• Grant date: May 21, 2002
• Expiry date: Jul 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel C3-substituted cyclodeca-1,5-diynes can be prepared through novel synthetic procedures using starting (E)-C3-substituted-4-(aryl- or heteroarylmethylidene)cyclodeca-1,5-diynes reagents. Both the C3-substituted cyclodeca-1,5-diyn-3-enes and the starting reagents have improved thermal stability compared to unsubstituted counterparts.