Process for preparing 4-(4′-carboxyphenyl)pyridine

US6392051B2 · kind B2 · utility

Assignee

• Clariant Corporation · DE

Inventors

• Andreas Meudt · Hofheim, DE
• Stefan Scherer · Büttelborn, DE
• Peter Koch · Frankfurt, DE
• Gerhard Demmer · Kelkheim, DE
• Frank Vollmuller · Frankfurt am Main, DE

Key dates

• Filing date: Feb 15, 2001
• Grant date: May 21, 2002
• Expiry date: Feb 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for preparing 4-(4′-carboxyphenyl)pyridine, which comprises oxidizing a 4-phenyl-N-acyldihydropyridine of the formula (II) whereR1 is a bulky alkyl, alkylaryl, arylalkyl or alkoxy group andR2 is a straight-chain or branched, substituted or unsubstituted alkyl radical having from 1 to 8 carbon atoms,by means of an oxidizing agent selected from the group consisting of permanganates, nitric acid, Cr(VI) compounds, oxygen and air to give the compound of the formula (I) where M is a cation.