Method for evaluating the quality of comparisons between experimental and theoretical mass data
US6393367B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 2000 |
| Grant date | May 21, 2002 |
| Priority date | — |
| Expiry date | Feb 19, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
A method for determining the probability that a biological molecule identification is incorrect for a chosen significance level is provided. The method includes comparing experimental mass data of an unknown biological molecule with theoretical mass data and calculating a score for each comparison; selecting at least two scores from the scores to form a primary data set; generating artificial data sets from the primary data set; calculating a sample mean for each artificial data set; estimating population mean and population standard deviation from the sample means wherein the population is based on the distribution underlying the primary dataset; computing a Z score from the population mean and population standard deviation for each score to standardize the scores; choosing a significance level; and comparing a test Z score to a Z score of the chosen significance level to determine the probability that the biological molecule identification is incorrect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.