Vivo induction for enhanced function of isolated hepatocytes
US6394812B1 · kind B1 · utility
25Cited by
8References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 24, 2000 |
| Grant date | May 28, 2002 |
| Priority date | — |
| Expiry date | Jul 24, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.