Method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament

US6394994B1 · kind B1 · utility

Assignee

• Vyteris, Inc. · US

Inventors

• NRK Vilambi · Elmont, US
• Bruce M. Eliash · Los Angeles, US
• Preston Keusch · Hazlet, US
• Lue H. Li · Hillsborough Township, US
• Elena N. Chabala · Jersey City, US
• Uday Jain · Rahway, US
• Louis J. Mestichelli · Doylestown, US

Key dates

• Filing date: Aug 27, 1999
• Grant date: May 28, 2002
• Expiry date: Aug 27, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/0428
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament includes providing an iontophoretic reservoir-electrode with a contact surface having a shape, a suitable electrical connection and a hydrated bibulous reservoir containing an ionized medicament. The method further includes providing another electrode operating a at preselected polarity opposite to the preselected polarity of the medicament reservoir-electrode. The method further includes providing a separation medium having the property of allowing passage therein to of ions of one charge. The separation medium is positioned between the reservoir electrode with the ionized medicament and the another electrode. The method also includes applying a sufficient electrical potential between the iontophoretic reservoir-electrode containing the ionized medicament and the another iontophoretic reservoir-electrode so that a current flows through the separation medium for a preselected time thereby transporting a quantity of the ionized medicament into the separation medium. The method then includes determining an amount of the ionizable medicament in the separation medium.