Biodegradable implant precursor

US6395293B2 · kind B2 · utility

Assignee

• Atrix Laboratories, Inc. · US

Inventors

• Alan M. Polson · Fort Collins, US
• Deryl D. Swanbom · Fort Collins, US
• Richard L. Dunn · Fort Collins, US
• Charles P. Cox · Fort Collins, US
• Richard L. Norton · Fort Collins, US
• Bryan K. Lowe · Fort Collins, US
• Kenneth S. Peterson · Keasbey, US

Key dates

• Filing date: Mar 8, 2000
• Grant date: May 28, 2002
• Expiry date: Mar 8, 2020

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29K2995/006
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.