Macrolide antiinfective agents

US6395710B1 · kind B1 · utility

Assignee

• Kosan Biosciences Incorporated · US

Inventors

• Daniel Chu · Santa Clara, US
• Gary Ashley · Alameda, US

Key dates

• Filing date: Apr 14, 2000
• Grant date: May 28, 2002
• Expiry date: Apr 14, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula whereinRa is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20); or ORa is replaced by H;Rb is H or halogen;Rc is H or a protecting group;Rd is methyl, unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C);Re is H or a protecting group;L is methylene or carbonyl;T is —O—, —N(R)—, —N(OR)—, —N(NHCOR)—, —N(N═CHR)—, or —N(NHR)— wherein R is H or Ra as defined above, with the proviso that when L is methylene, T is —O—;one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, …