Multibinding inhibitors of cyclooxygenase-2
US6395724B1 · kind B1 · utility
11Cited by
6References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1999 |
| Grant date | May 28, 2002 |
| Priority date | — |
| Expiry date | Jun 7, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.