Capsular polysaccharide adhesin antigen, preparation, purification and use
US6399066B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 10, 1999 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Sep 10, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains, and a general method to prepare such adhesins, are described. Vaccines composed of such adhesins, and uses of such adhesins to produce polyclonal and monoclonal antibodies against such adhesins, are also disclosed. The adhesins are useful in coating polymeric medical materials to prevent colonization by coagulase-negative staphylococcal strains, and as a probe in selecting desirable polymeric medical materials. Such adhesin antibodies are useful in vivo to prevent infection by nosocomial coagulase-negative staphylococcal strains, in assays for the detection of such bacteria, in assays for the estimation of such adhesins in complex mixtures, and as an affinity chromatography matrix.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.