Antimicrobial/endotoxin neutralizing polypeptide
US6399570B1 · kind B1 · utility
15Cited by
8References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 5, 1999 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Feb 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a 6 kDa host-defense polypeptide which is generated by proteolytic digestion of the lactoferrin molecule. The 6 kDa host-defense polypeptide has antimicrobial activity and also endotoxin-neutralizing activity. Also disclosed are functional variants of the 6 kDa host defense polypeptide, which include N-terminal and C-terminal truncations of the 6 kDa polypeptide, and other modifications of the polypeptide, such as amino acid substitutions which preserve or enhance activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.