Pyrazine derivatives, their preparation and medicaments containing them

US6399613B1 · kind B1 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Georges Bashiardes · Thiais, FR
• Jean-Christophe Carry · Saint-Maur-des-Fossés, FR
• Michel Evers · La Queue-en-Brie, FR
• Bruno Filoche · Créteil, FR
• Serge Mignani · Livry-Gargan, FR

Key dates

• Filing date: Jan 14, 2000
• Grant date: Jun 4, 2002
• Expiry date: Jan 14, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula: in whichR represents a nitrogen atom, R1 and R3 each represent the same radical selected from the group consisting of —CO—NR5R6, —CO—N(CH(CH2OH)2)2, —CO—N(CH2OH)2, —CO—N(CH2—CH(CH2OH)2)2, —CO—N(CH2—(CHOH)n—CH2OH)2 in which n is equal to 0, 1, 2, 3 or 4, —CH2—O—R6, —NR5—CO—R6, —CH2—NR5R6, —CH2—N(CH2OH)2, —CH2—N(CH2—(CHOH)y—CH2OH)2 in which y is equal to 0, 1, 2, 3 or 4, —CH2—N(CH(CH2OH)2)2 and —CH2—N(CH2—CH(CH2OH)2)2 and R2 and R4 each represents a hydrogen atom,R5 represents a hydrogen atom or an alkyl radical,R6 represents a radical —CH2—(CHOH)m—CH2OH in which m is equal to 0, 1, 2, 3 or 4, -alk-O-alk-CH2OH, -alk-O-alk, —CH(CH2OH)2, —C(CH2OH)3, —C(CH3) (CH2OH)2, —CH2—CH(CH2OH)2 or —CH(CH2OH)—(CHOH)x—CH2OH in which x is equal to 1, 2, 3 or 4, alk represents an alkyl radical, the alkyl radi…