Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists

US6399620B1 · kind B1 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Jochen Knolle · Kriftel, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Jean-Francois Gourvest · Claye-Souilly, FR
• Denis Carniato · Marcoussis, FR
• Thomas Gadek · Oakland, US
• Robert McDowell · San Francisco, US
• Robert Pitti · Corona, US
• Sarah C. Bodary · San Francisco, US

Key dates

• Filing date: Jun 29, 2000
• Grant date: Jun 4, 2002
• Expiry date: Jun 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are described cycloalkyl derivatives of the formula (I)R1—Y—A—B—D—E—F—G  (I)in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.