Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6399789B1 · kind B1 · utility
9Cited by
17References
11Claims
0Family size
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Key dates
| Filing date | Apr 12, 2000 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Apr 12, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.