Process for the preparation of &agr;' chloroketones
US6399793B1 · kind B1 · utility
3Cited by
2References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 18, 2001 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Jul 18, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of &agr;′ chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.