Process for the preparation of amino acid derivatives

US6399809B1 · kind B1 · utility

Assignee

• Degussa AG · DE

Inventors

• Wolfgang Kleemiss · Haltern, DE
• Marcel Feld · Cologne, DE

Key dates

• Filing date: Apr 21, 2000
• Grant date: Jun 4, 2002
• Expiry date: Apr 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C273/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the preparation of amino acid derivatives of the general formula I where R1-R4 are as defined herein,from the corresponding malonic acid monoester amides of the general formula II  by Hofmann degradation using a hypohalite in an aqueously basic medium, which comprises carrying out the reaction in the presence of an alcohol or amine and using the hypohalite in amounts of from 1.0 to 1.5 equivalents and the base in amounts of from 0.8 to 4.0 equivalents per mole of starting material II.