Methods for producing chiral aldehydes

US6399834B1 · kind B1 · utility

Assignee

• Studiengesellschaft Kohle gGmbH · DE

Inventors

• Walter Leitner · Aachen, DE
• Sabine Kainz · Moers, DE
• Daniel Koch · Shanghai, CN
• Giancarlo Francio · Nùgoro/Nuoro, IT

Key dates

• Filing date: May 15, 2001
• Grant date: Jun 4, 2002
• Expiry date: May 15, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for producing chiral aldehydes by the enantioselective hydroformylation of prochiral substrates with the aid of a catalyst consisting of a transition metal and a chiral ligand, characterized in that said chiral ligand is a compound of general formula 1 wherein the rings R7-R10 drawn with dotted lines are optional and one or more of rings R1-R6 or R7-R10 are substituted with one or more independently selected substituents of general formula —(CH2)x(CF2)yF(x=0-5; y=1-12) or their branched isomers. In particular, the invention relates to the conducting of the mentioned methods in compressed (liquid or supercritical) carbon dioxide as the reaction medium.