Immunomodulatory pharmaceutical composition adopted to form lyotrophic liquid crystals in contact with an aqueous phase
US6403122B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 12, 1997 |
| Grant date | Jun 11, 2002 |
| Priority date | — |
| Expiry date | Sep 12, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions especially for internal application which create lyotropic liquid crystals when in contact with aqueous phase. The pharmaceutical compositions consist of:A hydrophobic active ingredient with immunomodulatory effect from a group of N-methylated cyclic undecapeptides or macrolide antibiotics, in quantity 1-35 weight % in a carrier medium containingB at least one absorption promoter allowing for contact of the drug with a biological membrane or passing of the drug through in quantity 1-40 weight %,C nonlipidic vehicle containing at lest one of the below mentioned substances:C1 surfactant or mixed surfactant with HLB>9, in quantity 1-80 weight %C2 lipophilic solvent from group of higher fatty alcohols in quantity 1-30 weight %C3 at least one cosurfactant in quantity 1-50 weight %,while a ratio among the individual components of the product is A:B:C=1:0.5-4:5-8.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.