Systems for the mass production of proteins or peptides by microorganisms of the genus humicola
US6403362B1 · kind B1 · utility
12Cited by
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4Claims
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Key dates
| Filing date | Mar 3, 1999 |
| Grant date | Jun 11, 2002 |
| Priority date | — |
| Expiry date | Mar 3, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/823
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An expressing system which enables a large amount of production of a protein in Humicola, in particular, Humicola insolens, and particularly host-vector systems and a process for producing a protein using the systems, wherein an expression vector comprising the regulator sequences, i.e., the promoter, the signal sequence, and the terminator, of the cellulase NCE1 gene or NCE2 gene derived from Humicola insolens is constructed and used. The expression vector enables highly efficient production of cellulase NCE4, for example, in Humicola insolens at a rate as high as about 4.5 g or more per one liter of culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.