Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives

US6403581B1 · kind B1 · utility

Assignee

• American Cyanamid Company · US

Inventors

• Semiramis Ayral-Kaloustian · Tarrytown, US
• Douglas B. Kitchen · Schenectady, US
• Andrei Shavnya · East Lyme, US

Key dates

• Filing date: Jan 19, 2001
• Grant date: Jun 11, 2002
• Expiry date: Jan 19, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4439
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is a method of treating, inhibiting or controlling a ras-associated disease by inhibiting farnesyl-protein transferase(FPTase) enzyme, treating ras oncogene-dependent tumors, which include cancers of pancreas, breast, lung, colon, epidermis, prostate, bladder, thyroid, myelodysplastic tumors and myeloid leukemia; controlling metastasis, suppressing angiogenesis, inducing apoptosis, and in treating Ras-associated proliferative diseases other than cancer, such as restenosis, neuro-fibromatosis, endometriosis, and psoriasis, in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, Q, a, and b are defined in the specification.