Inhibitors of factor Xa with a neutral P1 specificity group

US6403620B1 · kind B1 · utility

Inventors

• Robert A. Galemmo, Jr. · San Francisco, US
• Celia Dominguez · Los Angeles, US
• John M. Fevig · McKeesport, US
• Qi Han · Wilmington, US
• Patrick Lam · Chadds Ford, US
• Donald J. P. Pinto · Kennett Square, US
• James R. Pruitt · Landenberg, US
• Mimi L. Quan · Newark, US

Key dates

• Filing date: Sep 10, 1999
• Grant date: Jun 11, 2002
• Expiry date: Sep 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.