Heterocyclic antituberculosis agents
US6403623B1 · kind B1 · utility
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16Claims
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Key dates
| Filing date | May 25, 2000 |
| Grant date | Jun 11, 2002 |
| Priority date | — |
| Expiry date | May 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/425
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method for treating tuberculosis with 2-(2-substituted-phenyl)-2-oxazolines and related 5-membered heterocycles represented by the formula Y1 is e.g. an ester or amide forming group, and X is O, S, or NH; and pharmaceutically acceptable formulations useful therein are provided. A preferred method comprises administering (S)-benzyl2-[2-(benzyloxy)phenyl]-2-oxazoline-4-carboxylate in a suitable formulation.The compounds of the above formula are prepared by known methods, e.g. the oxazolines are obtained by coupling a substituted benzoic acid with a serine ester or threonine ester and cyclizing the coupled product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.