2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors

US6403638B1 · kind B1 · utility

Assignee

• ALLERGAN SALES, LLC · US

Inventors

• Vidyasagar Vuligonda · Irvine, US
• Kwok Yin Tsang · Irvine, US
• Jayasree Vasudevan · Anaheim, US
• Roshantha A. Chandraratna · معلمی نژاد, US

Key dates

• Filing date: Mar 21, 2000
• Grant date: Jun 11, 2002
• Expiry date: Mar 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity.