High-efficiency multiple probe imaging system
US6403947B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 16, 2000 |
| Grant date | Jun 11, 2002 |
| Priority date | — |
| Expiry date | Mar 16, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/6452
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An imaging system is disclosed which provides means for obtaining images with essentially diffraction-limited spatial resolution, and can distinguish between several species of probes within a sample. It may be used with fluorescent, luminescent, up-converting reporter, quantum dot, and other types of probes. Two or more exposures are taken through a filter which expresses different filter states, one of which is preferably a relatively neutral state with high transmission for all wavelengths of interest, and the others of which provide predetermined variation in transmission that are preferably sloping or periodic in wavelength. The probe species is identified by the ratio of response at the various filter settings.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.