Solvent susceptibility compensation for coupled LC-NMR
US6404193B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 9, 2001 |
| Grant date | Jun 11, 2002 |
| Priority date | — |
| Expiry date | Apr 9, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/56536
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus in which the limitation upon analysis caused by variation of the magnetic susceptibility of the solvent conveying a sample to an NMR spectrometer can be addressed. The solvent composition which is used to bring about elution of analyte from devices such as chromatography columns can be varied without causing a corresponding variation of the solvent composition used to transport the analyte to the NMR spectrometer. The decoupling is achieved by the summing into the chromatographic stream, post column, a solvent composition which is complementary to the instantaneous composition emerging from the column, such that the magnetic susceptibility of the summed streams remains constant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.