Orthorhombic crystalline form of fluticasone propionate and pharmaceutical compositions thereof
US6406718B1 · kind B1 · utility
35Cited by
5References
28Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 15, 1999 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | Apr 15, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a new polymorphic crystalline form of S-fluoromethyl 6&agr;,9&agr;-difluoro-11&bgr;-hydroxy-16&agr;-methyl-3-oxo-17&agr;-propionyloxyandrosta-1,4-diene-17&bgr;-carbothiate (fluticasone propionate). The new polymorphic crystalline form is easily handled and easily fluidised and its particle size and shape can be controlled. The invention also relates to the use of this new material in therapy, particularly in the treatment of respiratory disorders, e.g. asthma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.