Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
US6406841B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 20, 1994 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | Jun 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/14022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to a novel human T-cell lymphotropic, or leukemia, virus type II (HTLV-II) isolate designated NRA. HTLV-IINRA was originally isolated from a patient with atypical hairy cell leukemia. Preliminary restriction analysis of this isolate demonstrated that it differs genetically from the prototypical HTLV-II isolate Mo. HTLV-IINRA proviral molecular clones were obtained and the entire nucleotide sequence of the virus ascertained. The claimed invention is particularly directed toward the gp46 and p21e envelope proteins encoded by the env gene. Methods and kits for the detection of HTLV-II antibodies employing these envelope proteins are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.