Methods of enhancing effectiveness of therapeutic viral immunogenic agent administration
US6406861B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1999 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | Oct 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M1/3679
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.