Hexa-cyclic compound
US6407115B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | May 26, 1995 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | May 26, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Accordingly, an object of this invention is to provide a hexa-cyclic compound represented by the following general formula: wherein R1 and R2 individually represent a hydrogen atom, a hydroxyl group, a C1-6 alkyl group (“C1-6 alkyl group means an alkyl group having 1 to 6 carbon atoms. Hereinafter defined in the same manner.)The present inventors have conducted extensive studies for the purpose of obtaining camptothecin derivatives with more excellent activity and higher safety, as well as excellent characteristics required for a drug to be administered, and found that hexa-cyclic compounds obtained by the addition of a water-soluble ring to camptothecin had characteristics superior to camptothecin. This finding has led to the completion of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.