Antibodies to Mch2, an apoptotic cysteine protease
US6407215B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 17, 1999 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | Aug 17, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2&agr;, and an inactive isoform of it, Mch2&bgr;, are disclosed. Isolated nucleic acid molecules that encode Mch2&agr; and Mch2&bgr;, respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2&agr; and Mch2&bgr; having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2&agr; or Mch2&bgr;, and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2&agr; and/or Mch2&bgr; are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2&agr; are disclosed. Antisense compounds and methods of using the same are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.