Crystal forms of 9-substituted hypoxanthine derivatives
US6407237B1 · kind B1 · utility
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6Claims
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Key dates
| Filing date | Feb 16, 2000 |
| Grant date | Jun 18, 2002 |
| Priority date | — |
| Expiry date | Feb 16, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The bifunctional compound N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide monopotassium salt occurs in a number of crystal forms which differ in their stability. Of these forms, the most stable is designated Type I, which is a monopotassium salt monohydrate in which the water is held as water of crystallization. Other crystalline forms, designated Type II and Type III, convert to Type I. Methods are disclosed for the synthesis of Type I and for the conversion of Type II or Type III to Type I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.