Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
US6409988B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2000 |
| Grant date | Jun 25, 2002 |
| Priority date | — |
| Expiry date | Jul 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0453
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to radiolabeled compounds of Formula I: or salts thereof, whereR1 represents R8, R8O, R8SO2, R8SO or R8S in which R8 is tritiated or deuterated methyl;X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substitutedC6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond;R2 is hydrogen or amino; andR3-R7 are defined in the specification.The invention is also directed to methods of using such compounds for demonstrating specific insect GABA receptors, qualitatively screening for compounds acting on an insect GABA receptor or quantitatively assaying concentrations of a compound acting on an insect GABA receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.