Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
US6410245B1 · kind B1 · utility
43Cited by
5References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1998 |
| Grant date | Jun 25, 2002 |
| Priority date | — |
| Expiry date | Apr 1, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6875
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods for identifying agents that are ligands for nuclear receptors. The methods include conducting multiplexed assays utilizing positive hybrid systems, reverse hybrid systems, direct interaction assays and other assays to screen for ligands having activity with a receptor of interest. The methods can be performed in various multiplexing formats to produce a profile that can be used to categorize a test ligand relative to known agonists and antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.