Odorant receptors

US6410249B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• John Ngai · Boxborough, US
• David J. Speca · Berkeley, US
• David M. Lin · Ithaca, US
• Ehud Y. Isacoff · Berkeley, US
• Andrew H. Dittman · Berkeley, US
• Jinhong Fan · Berkeley, US

Key dates

• Filing date: Jul 19, 2000
• Grant date: Jun 25, 2002
• Expiry date: Aug 1, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/726
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.