Compounds useful for inhibition of farnesyl protein transferase
US6410541B2 · kind B2 · utility
17Cited by
17References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 24, 2001 |
| Grant date | Jun 25, 2002 |
| Priority date | — |
| Expiry date | Jan 24, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued.Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.