Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases

US6410580B1 · kind B1 · utility

Assignee

• Novartis AG · CH

Inventors

• Paivi Jaana Kukkola · Whitehouse Station, US
• Leslie Ann Robinson · Los Altos, US
• Junichi Sakaki · Kawasaki, JP
• Motowo Nakajima · Ashiya, JP

Key dates

• Filing date: Aug 2, 2000
• Grant date: Jun 25, 2002
• Expiry date: Aug 2, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) wherein W is —OH or —NHOH; X is an optionally substituted heterocycle, NR1SO2R2, heterocyclylalkythio, CONR2R3 or NR1COR2; Y, Z, R1-R3 and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are use for the treatment of related conditions.