Patent · US Expired

Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives

US6410732B2 · kind B2 · utility

4Cited by
6References
50Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 25, 2001
Grant dateJun 25, 2002
Priority date—
Expiry dateJan 25, 2021

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D219/06
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermediates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridancarboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.