Process for preparation of pharmaceutically desired chiral tetralone from tetralones
US6410794B1 · kind B1 · utility
7Cited by
8References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 3, 2000 |
| Grant date | Jun 25, 2002 |
| Priority date | — |
| Expiry date | Nov 3, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8877
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Improved processes for preparation of tetralones in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic tetralone derivative. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired tetralone derivative enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid loss.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.