Identification of broadly reactive DR restricted epitopes
US6413517B1 · kind B1 · utility
12Cited by
2References
2Claims
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Key dates
| Filing date | Jan 21, 1998 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Jan 21, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/868
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic residue in position 1 (Y, F, W, L, I, V, M) and a small, non charged residue in position 6 (S, T, C, A, P, V, I, L, M). In addition, allele-specific secondary effects and secondary anchors are defined, and these results were utilized to derive allele specific algorithms. By the combined use of such algorithms peptides capable of degenerate DR1, 4, 7 binding were identified.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.