Diagnosis for mutant APC by immunoassay

US6413727B1 · kind B1 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Utah · US
• Japanese Foundation for Cancer Research Cancer Institute · JP
• Zeneca Limited · GB

Inventors

• Hans Albertsen · Salt Lake City, US
• Rakesh Anand · Rastatt, DE
• Mary Carlson · Salt Lake City, US
• Joanna Groden · Cincinnati, US
• Philip John Hedge · Grafton, GB
• Geoff Joslyn · Salt Lake City, US
• Kenneth W. Kinzler · Baltimore, US
• Alexander Fred Markham · Crewe, US
• Yusuke Nakamura · Bunkyo, JP
• Andrew Thliveris · Salt Lake City, US
• Bert Vogelstein · Baltimore, US
• Raymond L. White · Salt Lake City, US

Key dates

• Filing date: May 25, 1995
• Grant date: Jul 2, 2002
• Expiry date: May 25, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/828
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.