Method for identifying compounds that inhibit or enhance activation of a transmembrane ligand for a receptor tyrosine kinase
US6413730B1 · kind B1 · utility
18Cited by
3References
5Claims
0Family size
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Key dates
| Filing date | Mar 12, 1999 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Mar 12, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of modulating the biological activity of a transmembrane ligand for an Elk-related receptor tyrosine kinase in a cell expressing the transmembrane ligand, comprising forming a complex between a purified and isolated oligomerized Elk-related receptor tyrosine kinase, or an isoform or an extracellular domain of the kinase, and a transmembrane ligand expressed on the cell, thereby affecting a pathway in the cell which is regulated by the transmembrane ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.