Expression plasmids
US6413768B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 2, 1998 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Dec 2, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/521
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two independent levels by: (1) removing sole dependence on balanced lethal maintenance systems; and (2) incorporating a plasmid partition system to prevent random segregation of expression vector plasmids, thereby enhancing their inheritance and stability. The Plasmid Maintenance System may be employed within a plasmid which has been recombinantly engineered to express a variety of expression products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.