Glycomimetics as selectin antagonists and pharmaceuticals having antiinflammatory activity

US6413936B1 · kind B1 · utility

Assignee

• GLYCOREX AB · SE

Inventors

• Wolfgang Schmidt · Frankfurt, DE
• Ulrich Sprengard · Gustavsburg, DE
• Gerhard Kretzschmar · Eschborn, DE
• Robert Klein · Palo Alto, US
• Horst Kunz · Mainz, DE

Key dates

• Filing date: Oct 30, 1996
• Grant date: Jul 2, 2002
• Expiry date: Oct 30, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel mimetics of the tetrasaccharides sialyl-Lewis-X and sialyl-Lewis-A having an improved action as inhibitors of cell adhesion, to a process for the preparation of these compounds and to their use as pharmacological active compounds and diagnostic agents.