Inducible phosphofructokinase and the Warburg effect
US6413939B1 · kind B1 · utility
20Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1997 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Oct 31, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a cancer malignancy diagnostic assay comprising obtaining a sample of a body fluid or tissue, performing a sequence identity assay to look for the presence of PFK-2 specific sequences; an anticancer pharmaceutical composition comprising a specific antisense oligonucleotide to the inventive isolated PFK-2 sequence and a pharmaceutically acceptable oligonucleotide carrier; and a method for finding therapeutically active anti-cancer compounds comprising screening compounds for activity to inhibit PFK-2 but not PFK.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.