Polymer composition for delivering a nucleic acid or derivative thereof
US6413941B1 · kind B1 · utility
31Cited by
6References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 3, 1998 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Aug 3, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the backbone and biologically active polyanionic molecule bound to the polymer. Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.