Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions

US6414008B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Henning Priepke · Warthausen, DE
• Uwe Ries · Biberach an der Riß, DE
• Jean-Marie Stassen · Bad Buchau, DE
• Wolfgang Wienen · Äpfingen, DE

Key dates

• Filing date: Oct 13, 2000
• Grant date: Jul 2, 2002
• Expiry date: Nov 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New disubstituted bicyclic heterocycles of general formulaRa—A—Het—B—Ar—E  (I)Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.