Biofunctional polymers prepared in supercritical fluid

US6414050B1 · kind B1 · utility

Assignee

• The University of Nottingham · GB

Inventors

• Steven Howdle · Wentworth Street, GB
• Vladimir Popov · Moscow, RU

Key dates

• Filing date: Jan 10, 2000
• Grant date: Jul 2, 2002
• Expiry date: Jan 10, 2020

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B05D2401/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions comprising an admixture of a biofunctional polymer substrate and a biofunctional material substrate adapted for use in or in association with the human or animal body, cultivated or uncultivated living matter and methods for making and using thereof are disclosed. The biofunctional material substrate retains bioactivity in the admixture. As disclosed, the compositions may be made by a process which comprises contacting a mixture of the substrates or their precursors with a supercritical fluid under supercritical conditions of reduced viscosity to plasticise and swell the biofunctional polymer substrate and under conditions of physical blending to distribute the biofunctional material substrate throughout the biofunctional polymer substrate, and releasing the supercritical fluid under subcritical conditions. Also disclosed are biofunctional polymer matrices and methods of making and using thereof.