Patent · US Expired

Process for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi] indole derivatives

US6414144B1 · kind B1 · utility

7Cited by
1References
9Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 2, 2001
Grant dateJul 2, 2002
Priority date
Expiry dateNov 2, 2021

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P25/24
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention provides processes for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1, 4]diazepino[6, 7, 1-hi]indole derivatives of the general formula: wherein: R is H, alkyl, acyl, or aroyl; R1, R2, R4 and R5 are H, OH, alkyl, cycloalkyl, alkoxy s, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino s, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; R3 is H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of central nervous system disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.