2-amino-9-alkylpurines: GABA brain receptor ligands
US6414147B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 1999 |
| Grant date | Jul 2, 2002 |
| Priority date | — |
| Expiry date | Dec 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein:W is oxygen or sulfur;X is (un)substituted lower alkyl; orX is (un)substituted aryl or heteroaryl;Y is hydrogen or lower alkyl;Z is lower alkenyl, lower alkynyl, or (un)substituted lower alkyl;T is (un)substituted aryl or heteroaryl.The compounds are highly selective agonists, antagonists, or inverse agonists for GABAa brain receptors, or prodrugs of agonists, antagonists, or inverse agonists for GABAa brain receptors. Thus these compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, Down's Syndrome, overdose with benzodiazepine drugs, and for the enhancement of memory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.